Enhancer of Zeste Homolog 2 Protein

A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.

Also Known As:

Enhancer of Zeste Homolog 2; Histone-Lysine N-Methyltransferase EZH2; Lysine N-Methyltransferase-6; EZH2, Histone-Lysine N-Methyltransferase; Histone Lysine N Methyltransferase EZH2; Lysine N Methyltransferase 6

Macromolecular Substances: 97
- Multiprotein Complexes: 128
  - Polycomb-Group Proteins: 227
    - Polycomb Repressive Complex 2: 351
      - Enhancer of Zeste Homolog 2 Protein: 659
Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - One-Carbon Group Transferases
      - Methyltransferases: 6046
        Protein Methyltransferases: 70
        Histone Methyltransferases: 1248
        Histone-Lysine N-Methyltransferase: 209
        Polycomb Repressive Complex 2: 351
        Enhancer of Zeste Homolog 2 Protein: 659
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Transcription Factors: 39842
    - Repressor Proteins: 30
      - Polycomb-Group Proteins: 227
        Polycomb Repressive Complex 2: 351
        Enhancer of Zeste Homolog 2 Protein: 659
  - Nuclear Proteins: 2740
    - Non-Histone Chromosomal Proteins: 44
      - Polycomb-Group Proteins: 227
        Polycomb Repressive Complex 2: 351
        Enhancer of Zeste Homolog 2 Protein: 659
  - Nucleoproteins: 1892
    - Non-Histone Chromosomal Proteins: 44
      - Polycomb-Group Proteins: 227
        Polycomb Repressive Complex 2: 351
        Enhancer of Zeste Homolog 2 Protein: 659

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